beta secretase bace | MyBrainTest

Merck Advances BACE Inhibitor Trial for Alzheimer’s Disease

Merck announced last month that it is moving ahead with MK-8931, an experimental BACE inhibitor drug designed to slow the production of amyloid beta protein in the brain, one of the hallmarks of Alzheimer’s disease. Beta secretase (BACE) inhibitors work by interfering with the process that creates amyloid beta protein in the first place, in… Read More »

Lilly Kills a BACE Inhibitor Trial for Alzheimer’s

Eli Lilly recently announced that they voluntarily halted a Phase II clinical trial for LY2886721, a beta secretase (BACE) inhibitor designed to slow down the progression of Alzheimer’s disease. The Lilly announcement indicated that the trial was halted due to abnormal liver test results in patients. It’s not clear if BACE inhibition itself was causing… Read More »